Peptides

Sh-Polypeptide-93

INCI: SH-POLYPEPTIDE-93

Reviewed by Emma · Last updated 2 Jun 2026

A peptide that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Sh-Polypeptide-93?

Sh-Polypeptide-93 is a peptide — a short chain of amino acids — designed to function as a skin conditioning agent. Peptides are naturally occurring in skin as building blocks of proteins like collagen, which provides structure and elasticity to the dermis.

This ingredient works primarily to improve the overall condition and feel of skin by supporting its structural proteins. It is typically used in concentrations that allow it to deliver conditioning benefits without requiring high doses.

How It Works

Peptides function by mimicking or supporting the body's natural amino acid chains. When applied topically, Sh-Polypeptide-93 supplies short-chain amino acids that skin can utilise for conditioning purposes. These molecules are small enough to penetrate the outer layers of skin, where they contribute to improved hydration and texture.

The ingredient may also signal skin cells to maintain or support existing collagen and elastin structures, though the precise mechanisms in vivo require further investigation.

Clinical Evidence & References

Research into skin aging demonstrates that loss of dermal collagen and epidermal thickness are key drivers of visible aging, alongside impaired skin barrier function. Peptides as a class have been investigated for their potential to support skin structure and hydration.

Evidence specific to Sh-Polypeptide-93 is limited in publicly available research. General peptide studies suggest benefits for skin conditioning and hydration, though individual peptides vary in efficacy and bioavailability. More targeted clinical data would help establish the specific contribution of this ingredient.

How to Use

Sh-Polypeptide-93 is typically found in serums, moisturisers, and treatment products. Apply to clean skin as part of your regular routine. It works well in layered skincare — apply lighter textures first, then seal with a moisturiser or facial oil to support absorption and retention of hydrating ingredients.

Safety & Precautions

Peptides are generally well-tolerated across skin types. As with any new ingredient, introduce it gradually and discontinue if irritation develops.

Frequently Asked Questions

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