Peptides

Silkworm Sh-Polypeptide-47

INCI: SILKWORM SH-POLYPEPTIDE-47

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Silkworm Sh-polypeptide-47

A silk-derived peptide that helps skin retain moisture and maintain structural integrity

Best For Skin Types

All, Dry, Combination, Mature

Addresses

Dryness, Hydration, Fine lines

Usage Frequency

Daily

What Is Silkworm Sh-Polypeptide-47?

Silkworm Sh-Polypeptide-47 is a peptide derived from silk protein, specifically processed from silkworm sources. Peptides are short chains of amino acids that can be absorbed by the skin and contribute to its structural support and hydration levels.

In skincare formulations, this ingredient functions primarily as a humectant—drawing water into the outer layers of skin—and as a skin conditioning agent, helping to improve texture and elasticity over time.

How It Works

As a humectant, Silkworm Sh-Polypeptide-47 binds water molecules and draws them into the epidermis, improving skin hydration from within the product layer rather than the deeper dermis. This plumping effect can temporarily reduce the appearance of fine lines and create a smoother skin surface.

The peptide components may also interact with the skin's protein structures, supporting the natural processes that maintain skin firmness and elasticity, though the precise mechanism in topical application remains an area of ongoing research.

Clinical Evidence & References

Silk-based materials are well-documented in biomedical research for their biocompatibility and non-toxic profile, suggesting they are unlikely to cause irritation or adverse reactions in most individuals. However, specific clinical studies on Silkworm Sh-Polypeptide-47 as a cosmetic ingredient are limited in the published literature.

The humectant and conditioning properties are consistent with the known behaviour of silk proteins in skincare, but robust efficacy data specific to this derivative would strengthen confidence in its performance claims.

How to Use

This ingredient works best when applied to damp skin, as it can help seal in water and maximise hydration benefits. It is typically found in serums, hydrating essences, and moisturisers. Layer it with other hydrating ingredients for optimal effect, and use consistently as part of your routine rather than occasionally for best results.

Safety & Precautions

Generally well-tolerated by most skin types. Rare reports of silk-related sensitivities exist, so those with known silk allergies should patch-test before widespread use.

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