Peptides

Sh-Polypeptide-86

INCI: SH-POLYPEPTIDE-86

Reviewed by Kate · Last updated 2 Jun 2026

A peptide that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Hydration

Usage Frequency

Daily

What Is Sh-Polypeptide-86?

Sh-Polypeptide-86 is a peptide—a short chain of amino acids—used in skincare formulations as a skin conditioning agent. Peptides are derived from protein breakdown and are used in cosmetics to help support the skin's natural structure and appearance.

This ingredient functions primarily as a skin conditioner, helping to maintain skin texture and suppleness. Like other peptides in skincare, it works at the surface level to support the skin's moisture retention and overall condition.

How It Works

Peptides like Sh-Polypeptide-86 condition the skin by forming a protective layer on the skin surface, helping to lock in moisture and improve skin feel. The amino acid chains can also interact with the uppermost layers of skin to enhance hydration and smoothness.

As a conditioning agent, it does not penetrate deeply into the dermis but rather works to optimise the appearance and tactile quality of the outer skin layers.

Clinical Evidence & References

Research on skin ageing emphasises the importance of maintaining skin hydration and surface condition as part of a comprehensive skincare approach. Peptides are understood to support skin conditioning, though individual peptides vary in their specific effects.

Evidence on Sh-Polypeptide-86 specifically is limited in published scientific literature. The ingredient is used as a skin conditioner based on its chemical properties, but robust clinical data on its efficacy in addressing particular skin concerns is not widely available.

How to Use

Sh-Polypeptide-86 is typically found in serums, moisturisers, and other leave-on formulations. It works well as part of a layered routine and can be used alongside other conditioning and hydrating ingredients. No specific usage restrictions apply, though as with any skincare product, patch testing is recommended if you have sensitive skin.

Safety & Precautions

Peptides are generally well-tolerated by most skin types. As with any ingredient, discontinue use if irritation occurs.

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