Cleansing Agent

Sodium Guaiazulene Sulfonate

INCI: SODIUM GUAIAZULENE SULFONATE

Reviewed by Daisy · Last updated 14 Aug 2026

A sulfonated derivative of guaiazulene with gentle surfactant and soothing properties

Best For Skin Types

All, Sensitive, Combination

Addresses

Sensitivity, Redness, Barrier repair

Usage Frequency

Daily

What Is Sodium Guaiazulene Sulfonate?

Sodium guaiazulene sulfonate is a water-soluble, chemically modified form of guaiazulene—a natural compound found in chamomile and yarrow essential oils. The addition of a sulphonate group makes it stable and suitable for use in skincare formulations, where it functions primarily as a mild surfactant.

Unlike harsher surfactants, sodium guaiazulene sulfonate is designed to cleanse without stripping, and retains some of the traditional anti-inflammatory and soothing properties associated with guaiazulene itself.

How It Works

As a surfactant, sodium guaiazulene sulfonate works by lowering the surface tension of water, allowing it to lift oils, dirt, and other impurities from the skin more effectively. Its molecular structure allows it to bind to both water and oil-based substances, making it an efficient cleansing agent.

The guaiazulene moiety may contribute additional soothing effects through its known anti-inflammatory behaviour, though the extent to which this is retained after sulphonation is not extensively documented in published research.

Clinical Evidence & References

Direct clinical evidence for sodium guaiazulene sulfonate in skincare is limited. Most studies on guaiazulene focus on the parent compound rather than this sulfonated derivative. Historical and traditional use suggests the ingredient has soothing properties, but modern randomised controlled trials specifically evaluating this ingredient are sparse.

It is generally regarded as a well-tolerated ingredient in cosmetic formulations, though individual sensitivity to surfactants varies. Further research would help clarify its efficacy compared to other mild cleansing agents.

How to Use

This ingredient is typically found in cleansers and gentle formulations. Use as directed by the product instructions—usually as part of a daily or twice-daily cleanse. If combining with other actives, allow time between application to monitor skin tolerance, particularly if you have sensitive skin.

Safety & Precautions

Generally well-tolerated and suitable for sensitive skin. As with all surfactants, overuse or use in very high concentrations may disrupt the skin barrier; follow product directions to avoid this.

Frequently Asked Questions

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