Peptides

Sr-Spider Polypeptide-1

INCI: SR-SPIDER POLYPEPTIDE-1

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Sr-spider Polypeptide-1

A peptide derived from spider silk proteins that conditions and protects the skin barrier

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Barrier repair, Sensitivity

Usage Frequency

Daily

What Is Sr-Spider Polypeptide-1?

Sr-Spider Polypeptide-1 is a peptide sourced from spider silk proteins, engineered for use in skincare and personal care formulations. Peptides are short chains of amino acids that can penetrate or interact with the skin's surface to deliver specific benefits. This particular peptide is valued for its conditioning and protective properties.

In skincare products, this ingredient functions primarily as a skin protectant and conditioner, helping to support the skin's outer layers and improve the feel and appearance of the complexion.

How It Works

Peptides work by interacting with the skin's surface and potentially communicating with skin cells to trigger beneficial responses. Sr-Spider Polypeptide-1 is thought to form a conditioning film on the skin, which can help lock in moisture and create a protective barrier against environmental stressors.

The spider silk-derived structure of this peptide may also provide structural reinforcement, helping to maintain skin firmness and elasticity over time.

Clinical Evidence & References

Evidence specific to Sr-Spider Polypeptide-1 is limited in peer-reviewed literature. The ingredient is relatively newer to cosmetic formulations and has not been extensively studied in published clinical trials.

What we know comes largely from manufacturer data and the broader understanding of how peptides function in skincare. Spider silk proteins are known to be durable and resilient in nature, which supports their theoretical use as conditioning and protective agents, but direct evidence of efficacy in human skin would strengthen confidence in these claims.

How to Use

This ingredient is typically found in serums, creams, conditioners and protective skincare products. It works well alongside other hydrating or barrier-supporting ingredients, though no specific layering restrictions apply. Use as directed on product packaging, and introduce gradually if you are new to peptide-based products.

Safety & Precautions

Sr-Spider Polypeptide-1 is generally considered well-tolerated in cosmetic concentrations. As with any peptide ingredient, those with extreme sensitivity to proteins should patch-test first.

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