SYN-TC
INCI: Palmitoyl Tripeptide-5
Reviewed by Daisy · Last updated 18 Aug 2026
Also known as: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Proprietary peptide complex for under-eye circles
Addresses
EWG Safety Score
What Is SYN-TC?
SYN-TC is a proprietary peptide blend designed specifically to address under-eye darkness and puffiness. It works by improving microcirculation and reducing the accumulation of haemoglobin-derived pigments that contribute to dark circles.
This targeted peptide complex addresses the multifactorial nature of periorbital darkness, tackling both vascular and pigmentary components. It is commonly found in premium eye care formulations.
Clinical Evidence & References
- Journal of Cosmetic Dermatology, April 2022, pages 3,458–3,463 View Study
- Maibach, Howard I. and Gorouhi, Farzam. Textbook of ageing Skin, January 2016, pages 1–33 View Study
- Journal of Cosmetic Dermatology, June 2010, pages 108–116 View Study
- Journal of Clinical and Aesthetic Dermatology, March 2009, issue 3, pages 38-43 View Study
From the Clinic
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SYN-TC is a variant of Palmitoyl Tripeptide-5, the form you will most often see on an ingredients list.
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