Peptides

Tetrapeptide-1

INCI: TETRAPEPTIDE-1

Reviewed by Daisy · Last updated 14 Aug 2026

A peptide derived from ginseng that may support skin cell function and resilience

Best For Skin Types

All, Mature, Dry

Addresses

Dryness, Sensitivity, Barrier repair

Usage Frequency

Daily

What Is Tetrapeptide-1?

Tetrapeptide-1 is a short chain peptide (four amino acids linked together) originally isolated from Panax ginseng. It functions as a skin conditioning agent, working to maintain skin's structural integrity and support natural cellular processes.

Peptides are increasingly used in skincare because they are small enough to penetrate the skin barrier, yet signal to cells in meaningful ways. Tetrapeptide-1 specifically appears to have been studied for its potential to influence cell growth and tissue behaviour.

How It Works

Tetrapeptide-1 works by communicating with skin cells at a molecular level. Once absorbed into the skin, it interacts with cellular receptors, potentially triggering processes associated with healthy cell growth and maintenance.

Because it is derived from ginseng—a plant traditionally valued for its adaptogenic and supportive properties—the tetrapeptide may carry some of those cellular benefits into a topical formulation. However, the exact mechanism by which this particular tetrapeptide influences skin cells is not yet fully characterised in human skin studies.

Clinical Evidence & References

Research into tetrapeptide-1 has shown promise in cell culture models, where it demonstrated enhanced growth in certain cell types including human fibroblasts and epithelial cells. This suggests it may support healthy cell function and proliferation in the context of skin tissue.

Evidence in living human skin remains limited. Most studies have been conducted in laboratory conditions using cultured cells rather than in vivo (on human volunteers). Further research would help clarify whether these cellular benefits translate to visible or measurable skin improvements in real-world use.

How to Use

Tetrapeptide-1 is typically found in serums and moisturisers. Apply to clean skin as part of your regular routine. It pairs well with other hydrating or nourishing ingredients and can be used daily. As with any new ingredient, introduce it gradually if you have sensitive skin to monitor tolerance.

Safety & Precautions

Tetrapeptide-1 derived from ginseng is generally well-tolerated in skincare formulations. No significant safety concerns have been identified, though those with ginseng sensitivity should patch test first.

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