Tetrapeptide-20

Tetrapeptide-20 is a synthetic peptide — a short chain of amino acids — developed to mimic natural signalling molecules in the skin. It functions as a skin conditioning agent, helping to support the skin's structure and appearance.This ingredient works at a cellular level by engaging with specific receptors in the skin, potentially influencing processes related to melanin production and oxidative stress management within skin cells.

Tetrapeptide-20 is designed to act as an agonist of α-melanocyte-stimulating hormone (α-MSH), a naturally occurring signalling molecule. By mimicking this hormone's behaviour, the peptide communicates with melanocortin receptors on skin cells, potentially triggering cellular responses related to pigment production and stress resistance.Research suggests it may influence the activity of catalase, an enzyme that helps neutralise hydrogen peroxide — a compound involved in oxidative stress. This dual mechanism positions it as a peptide with both signalling and antioxidant-supporting properties.

Tetrapeptide-20 is typically found in serums and treatment products. As with most peptides, consistency matters — regular use over several weeks is generally recommended to observe any effects. It can be incorporated into both morning and evening routines and pairs well with other antioxidants and hydrating ingredients.

Tetrapeptide-20 is generally well-tolerated. As a peptide, it is unlikely to penetrate intact skin barrier significantly, making irritation uncommon. Those with known sensitivities to peptides should perform a patch test first.