Tetrapeptide-4

Tetrapeptide-4 is a short-chain peptide composed of four amino acids linked together. Peptides are fragments of proteins, and this particular sequence is designed to mimic or support natural signalling processes in the skin.In skincare formulations, tetrapeptide-4 functions primarily as a skin conditioning agent, helping to improve the feel and appearance of the skin's surface. It is synthetic and manufactured rather than derived from animal or plant sources.

Tetrapeptide-4 is believed to work through communication with skin cells, potentially signalling the skin to maintain or enhance its structural integrity. As a peptide, it may interact with cell receptors involved in collagen and elastin regulation, though the exact pathways are not fully characterised in published research.The ingredient also acts as a humectant and skin conditioning agent, meaning it can help the skin retain moisture and feel softer to the touch.

Tetrapeptide-4 is typically found in serums, moisturisers and treatment products. It can be used daily as part of a routine and pairs well with other conditioning or hydrating ingredients. There is no specific need to cycle this ingredient, and it is generally compatible with most other skincare actives including retinoids and vitamin C.

Tetrapeptide-4 is considered well-tolerated and gentle, with a low incidence of irritation reported. It is suitable for sensitive skin types, though as with any new ingredient, a patch test is sensible if you have known sensitivities.