Peptides

Tripeptide-5

INCI: TRIPEPTIDE-5

Reviewed by Kate · Last updated 2 Jun 2026

A peptide designed to support skin barrier function and hydration

Best For Skin Types

All, Sensitive, Dry

Addresses

Sensitivity, Dryness, Barrier repair

Usage Frequency

Daily

What Is Tripeptide-5?

Tripeptide-5 is a synthetic peptide composed of three amino acids linked together. Peptides are small protein fragments that can penetrate the outer layers of skin more readily than larger proteins, making them useful in topical skincare formulations.

In cosmetics, tripeptide-5 functions as a skin conditioning agent. It is typically incorporated into formulations at relatively low concentrations, where it is intended to interact with skin cells to support hydration and barrier health.

How It Works

Peptides work by interacting with skin cells at a molecular level. Their small molecular weight allows them to penetrate the stratum corneum (the skin's outer layer) more effectively than larger proteins. This enables them to communicate with deeper skin cells and potentially influence hydration and barrier function.

The specific mechanisms by which tripeptide-5 operates are not extensively detailed in published literature, but peptides in general are recognised for their ability to work at low concentrations due to their potency as active ingredients.

Clinical Evidence & References

Research indicates that peptides are used in approximately 17% of sensitive skin products from multinational brands, suggesting some industry confidence in their efficacy and tolerability. Studies have demonstrated that peptides can successfully penetrate the skin's outer layers and that formulations containing them are generally non-toxic and well-tolerated by skin cells.

However, published evidence specifically focused on tripeptide-5 and its independent efficacy is limited. Most research on this ingredient examines it as part of more complex delivery systems or formulations rather than its standalone effects. More robust clinical studies would help clarify its specific benefits.

How to Use

Tripeptide-5 is typically found in hydrating serums, moisturisers and sensitive skin products. Use as directed by the specific product formulation, usually once or twice daily. As with any skincare ingredient, introduce it gradually if you have reactive skin, allowing your skin to adapt over a week or two before assessing results.

Safety & Precautions

Tripeptide-5 is generally well-tolerated and is used in formulations designed for sensitive skin. As with all skincare ingredients, discontinue use if irritation occurs.

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