Peptides

Tripeptide-55

INCI: TRIPEPTIDE-55

Reviewed by Emma · Last updated 2 Jun 2026

A peptide with antioxidant properties designed to support skin's defence against environmental stress

Best For Skin Types

All

Addresses

Fine lines, Environmental damage, Premature ageing

Usage Frequency

Daily

What Is Tripeptide-55?

Tripeptide-55 is a short-chain peptide—a fragment of amino acids—formulated to provide antioxidant and skin-protective functions. Peptides are valued in skincare for their small molecular size, which allows better penetration into the skin, and their ability to signal specific benefits to skin cells.

This ingredient works primarily as an antioxidant, helping to neutralise free radicals that accumulate from sun exposure, pollution, and oxidative stress. By doing so, it aims to reduce the cellular damage associated with premature ageing and support the skin's natural defence mechanisms.

Benefits for Your Skin

How It Works

As the skin ages, it experiences a gradual loss of structural proteins like collagen and a decline in its natural defence systems. Environmental factors—particularly sun exposure—accelerate this process through the generation of free radicals, unstable molecules that damage skin cells.

Tripeptide-55 operates as an antioxidant, meaning it can donate electrons to free radicals and stabilise them, preventing them from causing further cellular damage. By reducing oxidative stress, the ingredient may help preserve skin integrity and support the skin's immune system in maintaining healthy tissue homeostasis.

Clinical Evidence & References

Research on skin ageing demonstrates that oxidative damage is a significant contributor to visible ageing, including loss of elasticity, wrinkle formation, and impaired barrier function. Antioxidant ingredients are widely recognised as part of a preventative skincare approach to address these concerns.

However, specific clinical data on Tripeptide-55 in peer-reviewed literature is limited. Whilst the ingredient is included in skincare formulations for its antioxidant and protective properties, independent clinical studies directly evaluating its efficacy remain sparse. Its inclusion in cosmetic products suggests formulators view it as a functional ingredient, but individual results may vary.

How to Use

Tripeptide-55 is typically found in serums, moisturisers, and targeted treatments. Apply it to clean skin, ideally in the morning or evening as part of your routine. It works well alongside other antioxidants and can be layered with other actives, though starting with one new ingredient at a time allows you to assess tolerance. Consistent use is more important than occasional application when addressing environmental damage.

Safety & Precautions

Peptides are generally well-tolerated across skin types with low irritancy potential. No significant safety concerns are documented for Tripeptide-55 at typical cosmetic concentrations.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations