Peptides

Tripeptide-69

INCI: TRIPEPTIDE-69

Reviewed by Kate · Last updated 2 Jun 2026

A peptide that supports skin hydration and conditioning

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Hydration, Fine lines

Usage Frequency

Daily

What Is Tripeptide-69?

Tripeptide-69 is a short-chain peptide—a compound composed of three amino acids linked together. Peptides are fragments of proteins that are small enough to be absorbed or utilised by the skin when applied topically, making them useful ingredients in skincare formulations.

In cosmetic products, tripeptide-69 functions as a humectant and skin conditioner. As a humectant, it helps draw moisture into the outer layers of the skin. As a skin conditioning agent, it helps maintain skin texture and suppleness by supporting the skin's natural moisture-retention capacity.

How It Works

Tripeptide-69 works primarily through its humectant properties. Humectants are substances with a chemical affinity for water molecules; they draw moisture from deeper layers of the skin and the environment into the stratum corneum (the outermost layer). This improves hydration at the skin surface and can help reduce the appearance of dryness and fine lines.

Additionally, as a peptide, it may provide conditioning benefits by coating the skin and helping to seal in moisture, which supports overall skin texture and elasticity over time.

Clinical Evidence & References

Research on skin ageing demonstrates that loss of dermal collagen and epidermal thinning are key features of aged skin. Peptides are studied as potential support agents for skin hydration and conditioning, given their small molecular size and ability to interact with the skin barrier.

Specific clinical evidence directly evaluating tripeptide-69's efficacy is limited in the published literature. The ingredient is used in cosmetic formulations primarily for its established humectant and conditioning functions. Further targeted research would help clarify its specific benefits and optimal concentration ranges for different skin concerns.

How to Use

Tripeptide-69 is typically found in serums, moisturisers, and hydrating treatments. Apply to clean, damp skin for optimum hydration benefit—damp skin allows humectants to draw moisture more effectively. Layer with an occlusive moisturiser if you have dry skin to seal in the hydration provided by the peptide. It can be used daily as part of your routine without special timing considerations.

Safety & Precautions

Tripeptide-69 is generally well-tolerated and considered safe for topical use in cosmetics. As with any ingredient, discontinue use if you experience persistent irritation or sensitivity.

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