Vitis Vinifera Leaf Extract
INCI: VITIS VINIFERA LEAF EXTRACT
Reviewed by Kate · Last updated 14 Aug 2026
A plant extract that may help support skin resilience and reduce inflammatory responses
Best For Skin Types
All, Sensitive, Combination
Addresses
Usage Frequency
Daily
What Is Vitis Vinifera Leaf Extract?
Vitis Vinifera Leaf Extract is derived from the leaves of the grapevine plant. It contains naturally occurring compounds including polyphenols and antioxidants that have been studied for their potential effects on skin cells.
In skincare formulations, it functions as a skin conditioning agent. The extract is used in relatively small amounts across skincare products, appearing in approximately 0.1% of formulations.
How It Works
The extract contains polyphenolic compounds that function as antioxidants, helping to neutralise free radicals generated by UV radiation and environmental stressors. This oxidative protection may reduce downstream inflammatory responses in skin cells.
Research suggests the extract may also influence gene expression in skin cells, potentially upregulating pathways associated with cellular protection and stress response. The exact mechanisms require further human studies to fully clarify.
Clinical Evidence & References
In vitro studies show that grapevine leaf extract can inhibit inflammatory mediators and oxidative stress markers in human keratinocytes when challenged with pro-inflammatory triggers or UV radiation. Research has also indicated potential anti-bacterial activity and effects on gene expression related to skin anti-aging pathways.
However, most evidence comes from laboratory studies on isolated cells rather than clinical trials in humans. Whilst these findings are encouraging, they represent early-stage research and larger human studies would be needed to confirm efficacy and optimal usage in skincare formulations.
Published Research
How to Use
Vitis Vinifera Leaf Extract is typically used as part of a broader skincare formula rather than as a standalone treatment. It works best when combined with a consistent routine that includes sun protection, as the extract's benefits appear most relevant when addressing UV-related damage and oxidative stress.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Vitis Vinifera Stem Extract
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Vitis Vinifera Vine Extract
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