Skin Conditioning

Vitis Vinifera Stem Extract

INCI: VITIS VINIFERA STEM EXTRACT

Reviewed by Daisy · Last updated 2 Jun 2026

A polyphenol-rich plant extract that conditions and protects the skin

Best For Skin Types

All

Addresses

Oxidative stress, Barrier repair

Usage Frequency

Daily

What Is Vitis Vinifera Stem Extract?

Vitis Vinifera Stem Extract is derived from the stems of the common grapevine plant. It is rich in polyphenols—naturally occurring plant compounds that include flavonoids, anthocyanins, and stilbenoids such as resveratrol. These bioactive molecules are responsible for the extract's skin conditioning and protective properties.

In skincare formulations, this ingredient functions primarily as a skin conditioner and protectant. It is used to help maintain skin barrier integrity and support the skin's natural defences, though the evidence for specific topical efficacy in humans remains limited.

How It Works

The extract works primarily through its high polyphenol content. These compounds are believed to function as antioxidants, helping to neutralise reactive oxygen species that accumulate from sun exposure, pollution, and normal skin metabolism. This antioxidant action may help protect skin cells from damage.

The extract may also support skin barrier function and have mild anti-inflammatory effects, though most of the mechanistic research has been conducted in laboratory settings or animal models rather than human skin. The specific pathways active in topical application remain less clearly defined than for some other botanical extracts.

Clinical Evidence & References

Research on grape-derived polyphenols shows promise in controlled laboratory and animal studies. Studies suggest that grape polyphenols possess antioxidant and anti-inflammatory properties, and some research indicates potential benefits for cellular health and stress resilience. However, most published research examines grape extracts from other plant parts (seed, skin, fruit) rather than specifically from the stems.

Evidence for topical efficacy in human skin is currently limited. While the ingredient appears well-tolerated, robust clinical trials demonstrating specific benefits for skin conditions in human subjects are lacking. It is best regarded as a supportive conditioning and protective ingredient rather than a treatment for specific skin concerns.

How to Use

Vitis Vinifera Stem Extract is typically found in serums, moisturisers, and protective skincare products. As it functions as a conditioning and antioxidant ingredient, it works well in formulations designed to support skin barrier health and defence. It is often combined with other plant extracts or antioxidants to create a more comprehensive protective system. There are no specific restrictions on frequency of use.

Safety & Precautions

This ingredient is generally well-tolerated by most skin types. Allergic contact dermatitis is possible but uncommon. Those with known sensitivity to grape or plant-derived ingredients should perform a patch test first.

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