Acetyl Tetrapeptide-71

Acetyl Tetrapeptide-71 is a synthetic peptide—a short chain of amino acids—designed to mimic natural signalling molecules in the skin. Peptides are thought to communicate with skin cells to support their normal functions, particularly around barrier maintenance and hydration.This ingredient functions as an emollient and humectant, meaning it helps soften the skin surface and draw moisture into the outer layers. It also acts as a skin conditioning agent, contributing to a smoother texture and improved skin comfort.

Peptides like Acetyl Tetrapeptide-71 are believed to work by signalling to skin cells, particularly fibroblasts and epidermal cells, to maintain or enhance their natural functions. The acetyl component may relate to cellular energy and lipid synthesis pathways that are crucial for barrier health.By supporting the skin's own ability to produce and maintain barrier lipids—the natural fats that hold moisture in—this peptide may help optimise hydration and skin resilience from within.

This ingredient is typically found in serums, moisturisers and barrier-repair products at concentrations that support its humectant and conditioning functions. Apply to clean skin, either alone or layered with other hydrating products. It pairs well with other peptides and hydrating ingredients like glycerin or hyaluronic acid for enhanced moisture support.

Acetyl Tetrapeptide-71 is generally well-tolerated in skincare formulations. As with any peptide ingredient, those with known sensitivities to synthetic peptides should patch-test first.