Biotinoyl Hexapeptide-2 Amide

Biotinoyl Hexapeptide-2 Amide is a synthetic peptide — a short chain of amino acids — conjugated with biotin (vitamin B7). It functions as a skin conditioning agent in cosmetic formulations.The hexapeptide structure allows it to interact with the skin's surface and upper layers, whilst the biotin component may offer additional conditioning benefits. This ingredient is incorporated into skincare products at relatively low concentrations.

Peptides work by signalling to skin cells and supporting the extracellular matrix — the scaffolding that keeps skin firm and resilient. Biotinoyl Hexapeptide-2 Amide is thought to condition the skin surface and possibly influence cell behaviour through peptide-based signalling.The biotin moiety may contribute additional benefits related to skin health, though the primary function of this ingredient in formulations is skin conditioning rather than deep structural remodelling.

This ingredient is typically encountered in serums, moisturisers and targeted treatments. It works well alongside vitamins, hydrators and other peptides. Apply to clean skin and follow with a moisturiser if using a serum formulation. No special preparation or timing is required.

Generally well-tolerated across skin types. No significant safety concerns have been reported at typical use concentrations. Those with sensitivity to peptides or biotin should patch test first.