Peptides

Caprooyl Tetrapeptide-3 Amide

INCI: CAPROOYL TETRAPEPTIDE-3 AMIDE

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Caprooyl Tetrapeptide-3 Amide

A peptide derivative designed to support skin conditioning and maintain skin comfort

Best For Skin Types

All, Dry, Sensitive

Addresses

Dryness, Sensitivity, Barrier repair

Usage Frequency

Daily

What Is Caprooyl Tetrapeptide-3 Amide?

Caprooyl Tetrapeptide-3 Amide is a synthetic peptide—a short chain of amino acids—modified with a caproyl (ten-carbon) fatty acid attachment. This modification allows the ingredient to interact with skin more effectively than the peptide alone.

In skincare formulations, it functions primarily as a skin conditioning agent, helping to maintain skin's texture and overall appearance by supporting the skin's natural processes.

How It Works

The peptide component of this ingredient is thought to communicate with skin cells, whilst the fatty acid attachment helps it penetrate or remain effective at the skin surface. Together, these may signal skin to maintain optimal hydration and structural integrity.

The exact mechanism remains incompletely understood in published research, and the ingredient's effects are generally modest rather than transformative.

Clinical Evidence & References

Published clinical data specifically on Caprooyl Tetrapeptide-3 Amide is limited. Most evidence for this ingredient's effects comes from manufacturer data and in vitro studies rather than robust human trials.

As a peptide-based conditioning agent, it aligns with the broader category of peptides used in skincare, though individual peptides vary considerably in their efficacy. Any benefits are likely incremental when used in typical formulation concentrations.

How to Use

This ingredient is typically included in moisturisers, serums, and hydrating treatments. Use as directed on the product label. Results, if present, are usually subtle and may take several weeks of consistent use to become apparent. It works well alongside other hydrating or conditioning ingredients.

Safety & Precautions

Caprooyl Tetrapeptide-3 Amide is generally well-tolerated and regarded as safe for topical use. Allergic reactions are rare, though sensitivity to any ingredient is possible; patch test if you have particularly reactive skin.

Frequently Asked Questions

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