Peptides

Cocoyl Tetrapeptide-4

INCI: COCOYL TETRAPEPTIDE-4

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Cocoyl Tetrapeptide-4

A coconut-derived peptide that supports skin conditioning and hydration

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Cocoyl Tetrapeptide-4?

Cocoyl tetrapeptide-4 is a peptide derived from coconut sources, created by attaching a coconut-derived fatty acid chain to a short chain of four amino acids (a tetrapeptide). This combination gives the ingredient both water-binding and skin-conditioning properties.

In formulations, it functions primarily as a skin conditioner, helping to improve the feel and hydration of the skin's surface. Peptides like this one are thought to support the skin's natural moisturising processes and may help reinforce the skin's protective barrier.

How It Works

The peptide structure allows this ingredient to penetrate the outer layers of skin and interact with the skin's natural hydration mechanisms. The coconut-derived fatty acid component helps the ingredient bind to the skin and reduce transepidermal water loss, whilst the tetrapeptide portion may support the skin's conditioning and firmness.

Clinical Evidence & References

Published research on cocoyl tetrapeptide-4 specifically is limited. Most evidence comes from cosmetic chemistry studies and manufacturer data rather than independent clinical trials. The ingredient appears to function as a reliable skin conditioner and humectant based on its chemical properties and use history in cosmetic formulations.

How to Use

This ingredient is typically found in moisturisers, serums and hydrating treatments. It works well in combination with other humectants and emollients. Use as directed in your chosen product; there is no need for specific timing or frequency adjustments beyond the product's recommendations.

Safety & Precautions

Cocoyl tetrapeptide-4 is generally well-tolerated and has a low risk of irritation. Those with known sensitivities to coconut derivatives should patch-test first, though reactions are uncommon.

Frequently Asked Questions

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