Escin
INCI: aescin
Reviewed by Kate · Last updated 18 Aug 2026
Also known as: aescin
Main saponin of the horse chestnut tree Exhibits antioxidant properties
EWG Safety Score
What Is Escin?
Escin, also called aescin, is the main saponin (a type of carbohydrate) of Aesculus hippocastanum, or horse chestnut, a tree native to parts of Europe, Asia, the Middle East, and North America.
Like most plant extracts, it exhibits antioxidant properties. Of most interest though to researchers, however, is its potential to mitigate factors that can lead to inflammation. Though this research is primarily linked to oral use, there’s exciting potential for it to have the same benefits when applied topically as well.
Clinical Evidence & References
- Pharmacology, Toxicology & Pathology, December 2021, ePublication
- Journal of Basic and Clinical Physiology and Pharmacology, July 2020, ePublication
- Drug Development Research, November 2019, pages 921-932
- Drug Design, Development and Therapy, September 2019, pages 3425–3437
- Chinese Journal of Natural Medicines, February 2018, pages 105-112
Published Research
-
Escin (Aescin): Anti-inflammatory from horse chestnut Arch Pharm Res, 2016
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