Glycogen
Reviewed by Kate · Last updated 18 Aug 2026
Also known as: Polysaccharide, Sphingolipids
A complex sugar known as a polysaccharide | Offers water-binding properties so is a humectant
Addresses
EWG Safety Score
What Is Glycogen?
Glycogen is a polysaccharide of glucose, a sugar that’s naturally present in the body, including the skin. Although its cell-energizing and signaling roles in the body has been known for decades, only recently has its role in skin been elucidated.
As it turns out, glycogen naturally occurring in skin and applied topically has been shown to help maintain and replenish ceramides, a type of sphingolipid in skin’s moisture barrier. Along with barrier maintenance, glycogen helps provide antioxidant defense from various types of airborne particulate pollutants shown to prematurely age skin.
Glycogen in skin care is often made enzymatically from breaking down natural foods such as corn, grains, or starchy vegetables. It may also be made from bacterial fermentation or animal-derived. The usage level of glycogen in skin care is typically 0.05–0.3%, with the higher levels achieving greater anti-aging and hydrating benefits. Levels below 0.3% still offer efficacy when combined with similar ingredients. Glycogen is considered safe as used in cosmetics since it occurs naturally in the body and within skin.
Clinical Evidence & References
Published Research
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Journal of Applied Glycoscience, June 2021, pages 41–46 [https://pmc.ncbi.nlm.nih.gov/articles/PMC8367632/]
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Journal of Clinical Biochemistry and Nutrition, July 2020, pages 29–35 [https://pmc.ncbi.nlm.nih.gov/articles/PMC7417792/]
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Polymers, February 2018, pages 1–25 [https://www.mdpi.com/2073-4360/10/1/25]
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BBA Clinical, June 2016, pages 85–100 [https://pmc.ncbi.nlm.nih.gov/articles/PMC4802397/]
From the Clinic
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Glyceryl Acrylate/Acrylic Acid Copolymer
A synthetic polymer that helps formulations maintain texture whilst supporting skin hydration
Glycine
Amino acid that helps the body create proteins Produced by the body
Glycine Soja Seed Water
A plant-derived humectant that draws moisture into the skin
Glycol
A lightweight humectant that draws moisture into the skin and aids ingredient delivery
Glycolide
A synthetic polymer used in advanced skincare delivery systems rather than as a direct skincare ingredient
Glycoproteins
A type of protein linked to a sugar Considered a type of peptide
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