Niacinamide Riboside Chloride
INCI: NIACINAMIDE RIBOSIDE CHLORIDE
Reviewed by Kate · Last updated 14 Aug 2026
Also known as: Niacinamide Riboside Chloride
A form of vitamin B3 that works to protect skin and support its natural defences
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Niacinamide Riboside Chloride?
Niacinamide riboside chloride is a precursor to NAD+, a coenzyme involved in cellular energy production and repair mechanisms. It is a derivative of niacinamide (vitamin B3) and is designed to be converted within the skin to support metabolic and protective functions at the cellular level.
As an antioxidant and skin-protecting agent, this ingredient is included in skincare formulations to help defend against environmental stressors and support the skin's natural resilience.
Benefits for Your Skin
How It Works
Niacinamide riboside chloride is absorbed by the skin and converted into NAD+, a critical coenzyme in cellular energy metabolism. This supports the skin's natural repair and defence systems at a molecular level.
By enhancing cellular energy availability, it may help reinforce the skin's capacity to protect itself against oxidative stress and environmental damage, contributing to overall skin resilience.
Clinical Evidence & References
Research on niacinamide riboside in skincare is still emerging, with most mechanistic work conducted in cell studies rather than human clinical trials. The ingredient's theoretical benefits stem from what we know about NAD+ in cellular health and energy metabolism.
While the antioxidant and skin-protective properties are plausible based on its chemistry, direct evidence of efficacy in human skin is limited. It may be most effective as part of a broader antioxidant strategy rather than a standalone solution.
How to Use
This ingredient is typically used as part of a daily skincare routine. Apply to clean skin before heavier creams or oils. It can be combined with other antioxidants and active ingredients, though patch testing is advisable if your skin is sensitive or you are introducing multiple new products simultaneously.
Safety & Precautions
Frequently Asked Questions
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Niacinamide Hydroxybenzoate
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Niacinamide Thioctate
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Nicotinamide
Versatile B3 form for multiple skin concerns
Nicotinamide Adenine Dinucleotide
Cellular energy coenzyme for skin vitality
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