Nicotinamide Adenine Dinucleotide
INCI: NAD+
Reviewed by Kate · Last updated 18 Aug 2026
Cellular energy coenzyme for skin vitality
Addresses
EWG Safety Score
What Is Nicotinamide Adenine Dinucleotide?
Nicotinamide Adenine Dinucleotide (NAD+) is a crucial coenzyme found in every living cell, essential for hundreds of metabolic processes. In the skin, NAD+ levels decline with age, contributing to reduced cellular energy and repair capacity.
Topical NAD+ and its precursors aim to replenish cellular energy stores, supporting the skin's ability to repair damage and maintain youthful function. This emerging ingredient represents a cellular-level approach to anti-ageing skincare.
Clinical Evidence & References
- Current Nutrition Reports, September 2023, pages 445–464
- Plastic and Reconstructive Surgery, October 2022, pages 41S–48S
- Antioxidants, August 2021, pages 1–24
- Nature Reviews Molecular Cell Biology, February 2021, pages 119–141
- Pharmaceuticals, September 2020, pages 1–16
- Cell Metabolism, March 2018, pages 513–528
- Advances in Food and Nutrition Research, February 2018, pages 83–149
How widely it's used
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- NICOTINAMIDE ADENINE DINUCLEOTIDE
- INN Name
- nadide
- EC Number
- 200-184-4
- Function
- Skin Conditioning
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Niacinamide Riboside Chloride
A form of vitamin B3 that works to protect skin and support its natural defences
Niacinamide Thioctate
A niacinamide derivative combining vitamin B3 with antioxidant support
Nicotinamide
Versatile B3 form for multiple skin concerns
Nicotinamide Mononucleotide
A NAD-boosting precursor that may support skin resilience through cellular energy and antioxidant pathways
Nicotinic Acid
Active B3 form with circulation-boosting properties
Nordihydroguaiaretic Acid
Potent natural antioxidant from creosote bush
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.