Nicotinamide Adenine Dinucleotide
INCI: NAD+
Reviewed by Kate · Last updated 18 Aug 2026
Cellular energy coenzyme for skin vitality
Addresses
EWG Safety Score
What Is Nicotinamide Adenine Dinucleotide?
Nicotinamide Adenine Dinucleotide (NAD+) is a crucial coenzyme found in every living cell, essential for hundreds of metabolic processes. In the skin, NAD+ levels decline with age, contributing to reduced cellular energy and repair capacity.
Topical NAD+ and its precursors aim to replenish cellular energy stores, supporting the skin's ability to repair damage and maintain youthful function. This emerging ingredient represents a cellular-level approach to anti-ageing skincare.
Clinical Evidence & References
- Current Nutrition Reports, September 2023, pages 445–464
- Plastic and Reconstructive Surgery, October 2022, pages 41S–48S
- Antioxidants, August 2021, pages 1–24
- Nature Reviews Molecular Cell Biology, February 2021, pages 119–141
- Pharmaceuticals, September 2020, pages 1–16
- Cell Metabolism, March 2018, pages 513–528
- Advances in Food and Nutrition Research, February 2018, pages 83–149
Frequently Asked Questions
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Niacinamide Riboside Chloride
A form of vitamin B3 that works to protect skin and support its natural defences
Niacinamide Thioctate
A niacinamide derivative combining vitamin B3 with antioxidant support
Nicotinamide
Versatile B3 form for multiple skin concerns
Nicotinamide Mononucleotide
A NAD-boosting precursor that may support skin resilience through cellular energy and antioxidant pathways
Nicotinic Acid
Active B3 form with circulation-boosting properties
Nordihydroguaiaretic Acid
Potent natural antioxidant from creosote bush
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