Nicotinamide
INCI: Niacinamide
Reviewed by Rosie · Last updated 18 Aug 2026
Also known as: Vitamin B3
Versatile B3 form for multiple skin concerns
Addresses
EWG Safety Score
What Is Nicotinamide?
Nicotinamide, the amide form of Vitamin B3, is one of the most extensively researched and versatile skincare ingredients available. It offers an impressive range of benefits without the flushing effect that can occur with nicotinic acid.
This multitasking ingredient works through several mechanisms: boosting ceramide synthesis for barrier repair, inhibiting melanosome transfer for brightening, and reducing sebum production for pore refinement. Its excellent tolerability makes it compatible with virtually all other actives.
Clinical Evidence & References
- International Journal of Dermatology, February 2021, pages 166-173
- Biomolecules & Therapeutics, July 2019, pages 562-569
- Experimental Dermatology, February 2019, pages 15-22
- Dermatologic Therapy, September 2017, ePublication
- Journal of Investigative Dermatology, May 2017, page S116
- International Journal of Pharmaceutics, March 2017, pages 158-162
- Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
- Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
- Skin Pharmacology and Physiology, June 2014, pages 311-315
- International Journal of Pharmacy, January 2013, pages 192-201
- Dermatoendrocrinology, July 2012, pages 308-319
- International Journal of Toxicology, September 2005, pages 1-31
- Dermatologic Surgery, July 2005, pages 860-865
- International Journal of Cosmetic Science, October 2004, pages 231-238
- Journal of Cosmetic Dermatology, April 2004, pages 88-93
Frequently Asked Questions
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Nicotinamide is a variant of Niacinamide, the form you will most often see on an ingredients list.
Vitamin B3, and one of the easiest actives to live with
Related Ingredients
Niacinamide
Vitamin B3, and one of the easiest actives to live with
Niacinamide Hydroxybenzoate
A niacinamide derivative that provides antioxidant protection and skin conditioning benefits
Niacinamide Riboside Chloride
A form of vitamin B3 that works to protect skin and support its natural defences
Niacinamide Thioctate
A niacinamide derivative combining vitamin B3 with antioxidant support
Nicotinamide Adenine Dinucleotide
Cellular energy coenzyme for skin vitality
Nicotinamide Mononucleotide
A NAD-boosting precursor that may support skin resilience through cellular energy and antioxidant pathways
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