Peptides

Oligopeptide-91 Rh-Oligopeptide-1

INCI: OLIGOPEPTIDE-91 RH-OLIGOPEPTIDE-1

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Oligopeptide-91 Rh-oligopeptide-1

A peptide that supports skin's natural protective and conditioning functions

Best For Skin Types

All

Addresses

Fine lines, Loss of elasticity, Dryness, Barrier repair

Usage Frequency

Daily

What Is Oligopeptide-91 Rh-Oligopeptide-1?

Oligopeptide-91 Rh-Oligopeptide-1 is a synthetic peptide—a short chain of amino acids—designed to mimic or support natural skin proteins. Peptides are recognised in skincare for their ability to interact with skin cells and influence various biological processes.

This ingredient functions primarily as a skin conditioner and protectant, meaning it helps maintain skin's moisture balance and support its natural defence mechanisms. It is typically used in leave-on products at low concentrations.

How It Works

Peptides work by communicating with skin cells through specific receptors, potentially signalling cells to maintain or reinforce structural proteins like collagen. In the case of Oligopeptide-91 Rh-Oligopeptide-1, the mechanism likely involves supporting the skin's natural conditioning and protective responses.

The skin's barrier and structural integrity depend partly on an intact protein network. As skin ages, collagen production declines and the dermis thins. Peptide ingredients are formulated with the aim of helping skin cells maintain or support their natural functions during this process, though the degree of benefit depends on several factors including concentration and formulation.

Clinical Evidence & References

Research demonstrates that skin undergoes measurable structural changes with age—including thinning of the epidermis and dermis, loss of collagen, and impaired barrier function. These changes underpin common concerns like fine lines, loss of elasticity, and reduced resilience.

While peptides as a class are well-studied in cosmetic science, specific evidence for Oligopeptide-91 Rh-Oligopeptide-1 is limited in published literature. The ingredient is included in skincare formulations based on its theoretical ability to support skin conditioning and protection, but robust clinical data on its efficacy in human skin is not widely available. Further research would help clarify its practical benefits at typical use concentrations.

How to Use

This ingredient is typically found in serums, moisturisers, and creams intended for daily use. Since it functions as a skin conditioner and protectant, it works best as part of a consistent routine rather than as an occasional treatment. Layer it with other hydrating or protective ingredients to support overall skin health, and allow time for cumulative effects.

Safety & Precautions

Peptides are generally well-tolerated and suitable for most skin types. No specific contraindications are widely reported for this ingredient, though patch testing is advisable if you have known sensitivities to peptides or other synthetic ingredients.

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