Palmitoyl Oligopeptide-135

Palmitoyl oligopeptide-135 is a peptide—a short chain of amino acids—that has been modified with a palmitoyl group (a fatty acid component). This modification allows the ingredient to penetrate and interact with skin more effectively than unmodified peptides.In skincare formulations, it functions primarily as a skin conditioning agent, working to support the skin's structural integrity and help maintain a healthy skin barrier.

The palmitoyl modification allows this peptide to interact with skin cells more readily than unmodified peptides alone. Once applied, it is thought to work at a cellular level to support the skin's natural defence mechanisms and maintain the integrity of the outer layers.Peptides in skincare generally signal to skin cells to support natural repair and maintenance processes, though the specific mechanisms of action vary between different peptide structures.

This ingredient is typically incorporated into serums, moisturisers and targeted treatments for sensitive skin. Use as directed on the product label. It is generally compatible with other skincare ingredients and can be layered into a routine without particular restrictions, though patch testing is always wise when introducing new products.

Palmitoyl oligopeptide-135 is generally considered well-tolerated and is commonly found in products designed for sensitive skin. No significant safety concerns are documented in cosmetic use.