Palmitoyl Tetrapeptide-94

Palmitoyl Tetrapeptide-94 is a synthetic peptide—a short chain of amino acids attached to a fatty acid (palmitic acid). Peptides in skincare are thought to function as signalling molecules, communicating with skin cells to influence their behaviour and support structural proteins.This particular peptide appears in formulations designed to address signs of ageing, particularly in sensitive or delicate skin areas. The palmitic acid component helps the peptide penetrate and remain stable within the skin barrier.

Peptides are believed to work by mimicking natural signalling molecules in the skin. Palmitoyl Tetrapeptide-94 may communicate with fibroblasts—the cells responsible for producing collagen and elastin—to encourage the maintenance or synthesis of these structural proteins.The attached fatty acid (palmitoyl group) allows the peptide to interact more effectively with the skin's lipid-rich barrier, potentially enhancing penetration and stability in formulations.

Use as directed by the product label. Peptide-containing products are typically applied once or twice daily to clean skin, often in serums, creams, or targeted treatments like eye products. Consistency over weeks is more important than intensity—peptide benefits build gradually. Layer with hydrating or barrier-supporting ingredients if using for sensitive skin.

Peptides are generally well-tolerated and unlikely to cause irritation, making them suitable for sensitive skin formulations. As with any skincare ingredient, patch test if you have known sensitivities to cosmetic compounds.