Peptides

Palmitoyl Tripeptide-38

Reviewed by Daisy · Last updated 18 Aug 2026

Matrix-building peptide for deep wrinkle reduction

At a glance

Peptide Helps with Anti-Aging Hydrating May feed Fungal Acne

Addresses

deep wrinkles, loss of volume, loss of firmness, ageing

What Is Palmitoyl Tripeptide-38?

Palmitoyl Tripeptide-38, marketed as Matrixyl synthe'6, is an advanced peptide that stimulates the synthesis of six major constituents of the skin matrix: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin-5.

This comprehensive approach to matrix renewal makes it particularly effective for treating deep wrinkles and loss of skin density. Clinical studies have shown significant improvements in wrinkle depth and skin firmness.

How widely it's used

0.4%
of skincare products contain this ingredient — placing it in the top 50% of most-used ingredients.
Most common in: Treatments Moisturisers

Regulatory information

Standardised cosmetic-ingredient identifiers used by regulators.

Show identifiers
INCI Name
PALMITOYL TRIPEPTIDE-38
EC Number
-
Function
Skin Conditioning

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