Peptides

Pantothenic Acid/Yeast Polypeptide

INCI: PANTOTHENIC ACID/YEAST POLYPEPTIDE

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Pantothenic Acid/yeast Polypeptide

A peptide-derived conditioning agent that supports skin hydration and resilience

Best For Skin Types

All, Dry, Sensitive

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Pantothenic Acid/Yeast Polypeptide?

Pantothenic acid, also known as vitamin B5, is a water-soluble vitamin that plays a central role in cellular metabolism. In skincare formulations, it is often combined with yeast-derived polypeptides to create a conditioning complex that works to support the skin's natural moisture balance and structural integrity.

This ingredient functions primarily as a skin conditioning agent, helping to improve the feel and appearance of the skin surface by enhancing hydration and smoothness. The yeast polypeptide component provides amino acids and peptide-like compounds that may support skin resilience.

How It Works

Pantothenic acid is a precursor to coenzyme A, a molecule essential for numerous metabolic processes in skin cells. When applied topically, it helps support cellular energy production and lipid synthesis, both of which are important for maintaining a healthy skin barrier.

The yeast polypeptides in this complex provide amino acids that can be incorporated into skin proteins or function as humectants, drawing water into the outer layers of the skin. Together, these components work to condition the skin and reinforce its natural moisture-holding capacity.

Clinical Evidence & References

Pantothenic acid has been studied for its role in wound healing and barrier function, with evidence suggesting it supports cellular repair processes. However, clinical data specific to the pantothenic acid/yeast polypeptide combination in skincare is limited, and most supporting evidence comes from in vitro or animal studies rather than robust human trials.

The ingredient is widely used in cosmetic formulations and is considered safe and effective for general skin conditioning purposes. More rigorous human studies would help establish the magnitude of benefit from this specific combination.

How to Use

This ingredient is suitable for use in daily skincare routines as part of serums, moisturisers, or essences. It pairs well with other hydrating and conditioning ingredients and does not typically require special application techniques. Use as directed by your product instructions.

Safety & Precautions

Pantothenic acid and yeast-derived ingredients are generally well-tolerated by most skin types. Those with yeast sensitivities should patch test first, though topical use is distinct from ingestion.

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