Peptides

Pentapeptide-11

INCI: PENTAPEPTIDE-11

Reviewed by Rosie · Last updated 14 Aug 2026

A peptide that conditions skin and may support structural integrity

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Loss of firmness, Dryness

Usage Frequency

Daily

What Is Pentapeptide-11?

Pentapeptide-11 is a short chain of five amino acids—the building blocks of proteins. It functions as a skin conditioning agent, helping to improve the texture and feel of skincare formulations.

Peptides are used in cosmetics because they can interact with skin cells and may influence processes related to skin structure. Pentapeptide-11 is typically included in products targeting mature or ageing skin concerns, where supporting skin firmness and elasticity is a priority.

How It Works

Pentapeptide-11 works by communicating with skin cells to support natural processes involved in maintaining skin structure. As skin ages, collagen—the protein responsible for firmness—naturally declines. Short peptide chains like this one may signal to fibroblasts (collagen-producing cells) to maintain or support collagen synthesis.

The ingredient also acts as a humectant and conditioning agent, drawing moisture into the outer layers of skin and improving overall hydration and tactile smoothness.

Clinical Evidence & References

The evidence base for pentapeptide-11 is limited compared to other peptides. While peptides in general have demonstrated potential to support skin firmness and barrier function, specific clinical data on pentapeptide-11 alone is sparse in the published literature.

Broader research on skin ageing confirms that loss of dermal collagen and epidermal thinning are key drivers of visible age-related changes. Ingredients that may support collagen dynamics could theoretically address these changes, though direct evidence for pentapeptide-11's efficacy remains modest.

How to Use

Pentapeptide-11 is typically found in serums, moisturisers, and eye creams. It is generally stable in most formulations and can be layered with other actives. Use daily for best results, as peptides tend to work cumulatively over time. A product containing this ingredient should be applied to clean skin before heavier creams.

Safety & Precautions

Pentapeptide-11 is generally well-tolerated by most skin types. Some formulations containing this peptide may include other ingredients that trigger fungal acne sensitivity, so check the full ingredient list if you are acne-prone.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations