Papain
INCI: Papaya Extract
Reviewed by Emma · Last updated 18 Aug 2026
Papain is an enzyme derived from latex found within papaya fruits
EWG Safety Score
Papain products at Skintique
View all →What Is Papain?
Papain is an enzyme derived from latex found within papaya fruits. It’s typically used in skin care as an exfoliating agent.
Papain breaks down the adhesive proteins to help relieve skin’s surface of dead, dull cells. Exfoliation of dead skin cells can improve skin’s texture and promote an even tone. The catch? It must be a controlled experience, and that’s not the case with papain. Applied to skin, it just keeps “eating” cells, and that can lead to visible problems.
Although touted as a gentle, natural exfoliant, papain is a proven skin-sensitizer and can cause redness, itchiness, itchiness and dryness when applied topically. A study published in 2015 that explored papain’s impact on skin revealed that the ingredient can compromise the skin barrier, increase transepidermal water loss, cause visible reactions and degrade skin proteins.
It’s especially sensitizing when used in high concentrations or when applied directly from raw papaya.
As a raw material papain appears as a white-to-light-yellow powder. Supplies of papain recommend using 0.1%-0.5% concentrations of the ingredient in daily usage products and 0.5%-2.0% in more intense, weekly use products. We advise avoiding it in any amount!
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizPart of a family
Papain is a variant of Fruit Enzymes, the form you will most often see on an ingredients list.
Natural exfoliating enzymes from tropical fruits
Related Ingredients
Fruit Enzymes
Natural exfoliating enzymes from tropical fruits
Adansonia Digitata Seed Powder
A plant-derived powder that gently buffs away dead skin cells
AHA
AKA alpha hydroxy acid Exfoliates skin and improves visible signs of ageing
AHA - Alpha Hydroxy Acid
Water-soluble acids for surface exfoliation and renewal
Artemisia Montana Leaf Powder
A plant-derived powder with gentle physical exfoliating properties
Avena Sativa Bran Extract
A plant-derived exfoliant with potential antioxidant properties from oat bran
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.