Solvent

PEG-400

Reviewed by Daisy · Last updated 18 Aug 2026

A solvent and stabiliser that helps deliver other actives and maintain product texture

Best For Skin Types

All

Addresses

Hydration

Effective Concentrations

0-10%

Usage Frequency

Daily

What Is PEG-400?

PEG-400 is a polyethylene glycol, a synthetic polymer derived from petroleum. It functions as a humectant, solvent and emulsion stabiliser in skincare formulations. In practical terms, it helps dissolve ingredients that wouldn't normally mix well together and improves the overall stability and feel of a product.

PEG-400 appears in a small percentage of skincare products, typically at concentrations below 10%. Its primary role is structural rather than therapeutic—it enables formulators to create stable, homogeneous products and can help other actives penetrate the skin more effectively.

How It Works

PEG-400 is a hygroscopic substance, meaning it attracts and binds water molecules. When applied to skin, it draws moisture from deeper layers into the stratum corneum, supporting hydration. Additionally, its molecular structure allows it to dissolve ingredients that are otherwise insoluble in water or oils alone, enabling more effective formulation design.

Research suggests PEG-400 may also influence how the skin's outer layer behaves, potentially affecting the penetration pathway of other active ingredients. This makes it particularly useful in formulations designed to deliver specific actives deeper into the epidermis.

Clinical Evidence & References

Evidence on PEG-400 is limited compared to other skincare ingredients. Available research indicates it can enhance skin penetration of certain actives—particularly when combined with other solvents—though the magnitude of this effect varies depending on the active ingredient and formulation context.

Studies examining optical skin properties suggest PEG-400 may influence light scattering within skin tissue, though this research was conducted in specialised laboratory conditions and its relevance to routine skincare use remains unclear. Overall, PEG-400 functions more as a formulation tool than a primary active, so clinical evidence focuses on its role in delivery systems rather than standalone benefits.

How to Use

PEG-400 is typically a background ingredient rather than something you need to use strategically. Since it appears in small concentrations within formulations, simply use the product as directed. If you're using multiple products containing PEG-400, there's no concern about layering or interaction—the ingredient is present in too low a concentration to cause issues when combined with other formulations.

Safety & Precautions

PEG-400 is generally recognised as safe for skincare use and is well-tolerated across skin types. Some individuals with very sensitive skin may experience mild irritation, though this is uncommon.

Frequently Asked Questions

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Part of a family

PEG-400 is a variant of PEG-75, the form you will most often see on an ingredients list.

Functions as a humectant to boost skin’s hydration | May also be used as a solvent to mesh ingredients cohesively and enhance formulary texture

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