Peptides

Sh-Polypeptide-10

INCI: SH-POLYPEPTIDE-10

Reviewed by Daisy · Last updated 2 Jun 2026

A conditioning peptide that supports skin's structural integrity and texture

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Dryness, Hydration, Fine lines

Usage Frequency

Daily

What Is Sh-Polypeptide-10?

Sh-Polypeptide-10 is a peptide — a short chain of amino acids — used in skincare primarily for its skin-conditioning properties. Peptides are naturally occurring in the skin and play a role in maintaining its structure and function. This particular peptide is included in formulations to help improve the skin's texture and overall condition.

As a skin conditioner, Sh-Polypeptide-10 works at the surface level to support the skin's appearance and feel, rather than penetrating deeply into the dermis. It is typically found in serums, moisturisers and targeted treatments aimed at maintaining or improving skin quality.

How It Works

Peptides function by signalling to skin cells and supporting the proteins that maintain skin structure. Sh-Polypeptide-10 acts primarily as a skin conditioner, meaning it works at or near the surface to improve how the skin feels and appears, rather than triggering deeper biological changes.

The peptide can help smooth the skin's outer layer and may support the skin's natural moisture barrier, contributing to a more hydrated and refined appearance over time.

Clinical Evidence & References

Peptides as a class have a reasonable body of research supporting their role in skincare, though individual peptides vary in the depth of evidence available. Sh-Polypeptide-10 is less extensively studied in published clinical trials compared to some better-known peptides, so specific efficacy claims should be treated with appropriate caution.

The ingredient is generally recognised as safe and well-tolerated in cosmetic formulations, and its conditioning function is well-established in cosmetic chemistry, though visible benefits may be modest and develop gradually with regular use.

How to Use

Sh-Polypeptide-10 is typically used as part of a daily skincare routine in serums or moisturisers. It works well alongside other conditioning and hydrating ingredients, and can be layered into both morning and evening routines. Consistency of use is more important than frequency — regular application over weeks will yield better results than sporadic use.

Safety & Precautions

Sh-Polypeptide-10 is generally well-tolerated and suitable for most skin types, including sensitive skin. Peptides have a low risk of irritation, though those with known sensitivities should patch-test first.

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