Sh-Polypeptide-123

Sh-Polypeptide-123 is a synthetic peptide — a short chain of amino acids engineered to mimic natural protein structures found in skin. It belongs to a class of ingredients commonly used in skincare formulations to provide protective and conditioning benefits to the skin's outer layers.This ingredient functions primarily as a skin protectant, helping to support the skin barrier and maintain the skin's structural integrity. It does not penetrate deeply into the skin but rather works at the surface level to reinforce and maintain the skin's natural defence mechanisms.

Sh-Polypeptide-123 works primarily through surface film-forming and conditioning mechanisms. When applied, the peptide chains settle on the skin's surface, creating a protective layer that helps prevent transepidermal water loss — the evaporation of moisture through the skin barrier.The peptide's amino acid structure allows it to interact with the skin's natural proteins and lipids, reinforcing the barrier's cohesion without disrupting normal skin function. This is a passive protective mechanism rather than an active biochemical change within the skin.

This ingredient works best when applied to clean skin and can be used as part of your regular routine. It pairs well with hydrating and barrier-supporting ingredients such as ceramides, hyaluronic acid and glycerin. Allow the product to dry fully before applying additional layers or makeup, as this helps the protective film form effectively.

Sh-Polypeptide-123 is generally considered well-tolerated and safe for use in skincare products. As a synthetic peptide, it is unlikely to cause allergic reactions in most people, though those with known sensitivities to peptide ingredients should patch-test first.