Sh-Polypeptide-16

Sh-Polypeptide-16 is a synthetic peptide—a short chain of amino acids—created to mimic or support skin's inherent defence systems. Peptides are increasingly used in skincare because they can communicate with skin cells and support structural integrity.This ingredient is classified as a skin protectant, meaning its primary function is to help shield the skin from environmental stressors and support the skin barrier. It works at a cellular level rather than providing a surface-level occlusive barrier.

Peptides like Sh-Polypeptide-16 work by signalling to skin cells, essentially instructing them to strengthen their defensive mechanisms. The skin naturally relies on multiple layers of protection—physical barriers, immune cells, and chemical defences—and peptides can enhance these systems at a molecular level.Rather than acting as a topical barrier, this ingredient encourages the skin itself to be more resilient. This is particularly relevant as skin ages and its natural protective capacity diminishes due to collagen loss and reduced cell turnover.

Sh-Polypeptide-16 is typically found in serums, moisturisers, and targeted treatments. It works well alongside other skin-supporting ingredients such as antioxidants and humectants. Apply to clean skin and allow to absorb before layering other products. There is no upper limit to how frequently you can use products containing this ingredient, though following the specific product instructions is advisable.

Peptides are generally well-tolerated and suitable for most skin types, including sensitive skin. Discontinue use if irritation occurs, though this is uncommon with peptide ingredients.