Peptides

Sh-Polypeptide-13

INCI: SH-POLYPEPTIDE-13

Reviewed by Daisy · Last updated 2 Jun 2026

A peptide that supports the skin's natural protective barrier function

Best For Skin Types

All, Sensitive, Dry

Addresses

Barrier repair, Sensitivity, Dryness

Usage Frequency

Daily

What Is Sh-Polypeptide-13?

Sh-Polypeptide-13 is a peptide—a chain of amino acids—designed to support skin's protective mechanisms. Peptides are naturally occurring compounds found in the skin, and when formulated into skincare products, they can help reinforce the skin's structural integrity and defensive capacity.

This ingredient functions as a skin protectant, working to maintain and strengthen the skin barrier. The skin barrier is crucial for keeping irritants out and moisture in, making barrier support a foundational aspect of healthy skin maintenance.

How It Works

The skin relies on multiple layers of protection—physical, chemical, and immune-based—to defend itself and maintain function. Sh-Polypeptide-13 operates as a protective agent, helping to reinforce these natural defences. Peptides can signal to skin cells, encouraging them to maintain barrier function and structural proteins.

By supporting the skin's inherent protective systems, this ingredient helps create conditions for healthier barrier function. This is particularly relevant as the skin's protective capacity naturally declines with age and cumulative environmental exposure.

Clinical Evidence & References

Research on skin aging consistently demonstrates that the barrier weakens over time due to loss of structural proteins and impaired immune function. A stronger, well-maintained barrier is associated with better skin health, improved resilience, and reduced susceptibility to irritation and environmental damage.

While broad evidence supports the importance of barrier protection, specific clinical data on Sh-Polypeptide-13 is limited in the published literature. The ingredient is included in skincare formulations for its protective function, though individual efficacy studies would help establish its precise contribution to barrier repair and maintenance.

How to Use

Sh-Polypeptide-13 is typically used as part of a complete skincare routine rather than as a standalone treatment. It works well in serums, moisturisers, and protective products applied to clean skin. For best results, layer it with other barrier-supporting ingredients such as hydrating humectants or occlusive moisturisers to create a comprehensive protective strategy.

Safety & Precautions

Sh-Polypeptide-13 is generally well-tolerated across skin types. As with any skincare ingredient, discontinue use if irritation occurs and perform a patch test if you have sensitive or compromised skin.

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