Sh-Polypeptide-11

Sh-Polypeptide-11 is a short chain peptide—a fragment of amino acids—derived from protein hydrolysis. Peptides are valued in skincare because they are small enough to penetrate the skin barrier, yet large enough to signal cellular activity. This particular peptide is used in formulations at very modest concentrations, appearing in fewer than 1 in 500 skincare products.In topical formulations, Sh-Polypeptide-11 is theoretically designed to communicate with skin cells to encourage structural support, though its specific mechanism and efficacy in cosmetic products remain poorly characterised i…

Helps with Anti-Ageing. Hydrating. For the Look of Scars

Peptides like Sh-Polypeptide-11 work by penetrating the outer layers of skin and binding to cell receptors. Once absorbed, they can signal skin cells (particularly fibroblasts in the dermis) to increase their production of structural proteins such as collagen. This is distinct from applying collagen directly to the skin, which is too large to absorb.As skin ages, the dermis naturally loses collagen and becomes thinner. By stimulating the skin's own protein synthesis, peptides may help slow this process, though the evidence for this ingredient specifically is limited. Any effects would typic…

Sh-Polypeptide-11 is typically found in serums, moisturisers, and targeted treatments at low concentrations. For best results, use consistently as part of your daily routine—peptides work gradually, so allow at least 4–8 weeks of regular use before assessing efficacy. Layer it after cleansing and any water-based treatments, but before heavier creams or oils. It pairs well with sunscreen, which is equally important for slowing visible signs of ageing.

Peptides are generally well-tolerated and have a low risk of irritation or sensitisation. As with any new ingredient, patch test first if you have sensitive or reactive skin.