Peptides

Sr-Dog Polypeptide-4

INCI: SR-DOG POLYPEPTIDE-4

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Sr-dog Polypeptide-4

A peptide derivative that offers antioxidant and conditioning properties for skin and hair

Best For Skin Types

All

Addresses

Oxidative stress, Dryness, Barrier repair

Usage Frequency

Daily

What Is Sr-Dog Polypeptide-4?

Sr-Dog Polypeptide-4 is a peptide—a chain of amino acids—derived from dog sources and used in skincare formulations. Peptides function as signalling molecules in skin, potentially communicating with cells to support various protective and conditioning functions.

This particular ingredient is classified as an antioxidant and skin protectant, meaning it may help defend against environmental stressors and support the skin's natural barrier. It is also used for its hair conditioning properties in products designed for scalp and hair health.

Benefits for Your Skin

How It Works

As a peptide, Sr-Dog Polypeptide-4 can interact with skin cells through receptor-mediated pathways. Peptides are small enough to penetrate the outer skin layers and may trigger cellular responses that support natural skin defences and maintain structural integrity.

In its antioxidant capacity, the ingredient likely neutralises free radicals—unstable molecules generated by sun exposure, pollution and oxidative stress—that can contribute to skin damage and premature ageing.

Clinical Evidence & References

Published research specifically evaluating Sr-Dog Polypeptide-4 in human skin is limited. The ingredient is used in cosmetic formulations based on its theoretical antioxidant and conditioning properties, but robust clinical data demonstrating efficacy in skincare applications is not widely available.

Peptides as a class have shown promise in skincare research, though individual peptides vary significantly in their effects. Further independent studies would help establish the specific benefits and optimal concentrations of this ingredient.

How to Use

Sr-Dog Polypeptide-4 is typically incorporated into serums, moisturisers and conditioning treatments. There is no established upper limit for daily use; however, as with any active ingredient, introduce it gradually if your skin is sensitive and observe how your skin responds over 2-4 weeks before drawing conclusions about its effectiveness.

Safety & Precautions

Sr-Dog Polypeptide-4 is generally considered well-tolerated in cosmetic formulations. Those with sensitivity to animal-derived ingredients should check product labelling, though peptides are typically processed and purified during manufacture.

Frequently Asked Questions

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