Peptides

Sr-Dog Polypeptide-2

INCI: SR-DOG POLYPEPTIDE-2

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Sr-dog Polypeptide-2

A polypeptide that supports skin resilience and antioxidant defence

Best For Skin Types

All, Mature

Addresses

Fine lines, Dryness, Barrier repair

Usage Frequency

Daily

What Is Sr-Dog Polypeptide-2?

Sr-Dog Polypeptide-2 is a peptide derived from dog sources, designed to function as an antioxidant and skin-conditioning agent. Peptides are short chains of amino acids that can penetrate the outer layers of skin and interact with cellular structures to support various skin functions.

In skincare formulations, this ingredient is primarily used to help protect skin from oxidative stress and to improve the overall conditioning and texture of the skin. Its mechanisms centre on antioxidant activity and support for skin barrier health.

Benefits for Your Skin

How It Works

As an antioxidant, Sr-Dog Polypeptide-2 works by neutralising free radicals—unstable molecules generated by environmental stressors like UV exposure and pollution. This helps reduce oxidative stress, which is implicated in premature skin ageing and inflammation.

The peptide's conditioning properties allow it to interact with the skin's outer layers, improving hydration retention and enhancing skin texture. By supporting the skin's structural proteins, it may help maintain skin resilience and firmness.

Clinical Evidence & References

Research into lamin-associated polypeptides suggests these molecules play important regulatory roles in skin cell stability and ageing processes. Some evidence indicates that lamins and related polypeptides decline with age, which may relate to changes in skin texture and elasticity.

However, specific clinical data on Sr-Dog Polypeptide-2 itself in human skin is limited. While the ingredient's antioxidant and conditioning functions are plausible based on its chemical nature, robust human trials demonstrating efficacy in skincare remain sparse. Further research would help clarify its practical benefits in cosmetic applications.

How to Use

Sr-Dog Polypeptide-2 is typically used as part of a broader skincare formula rather than as a standalone treatment. It works well in serums, moisturisers, and hair conditioners. For best results, use consistently as part of your daily routine, and combine with a dedicated sunscreen to maximise antioxidant protection against environmental damage.

Safety & Precautions

This ingredient is generally well-tolerated in skincare products. As with any new ingredient, patch test before widespread use if you have particularly sensitive or reactive skin.

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