Peptides

Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1

INCI: SR-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1 SH-OLIGOPEPTIDE-1

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Sr-clostridium Botulinum Polypeptide-1 Sh-oligopeptide-1

A peptide derivative with antioxidant properties designed to support skin defence

Best For Skin Types

All, Sensitive, Mature

Addresses

Fine lines, Sensitivity, Redness

Usage Frequency

Daily

What Is Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1?

Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 is a peptide derived from bacterial sources and engineered for cosmetic use. Despite its origin, it contains no active toxin and is used solely for its antioxidant and skin-protective properties in skincare formulations.

Peptides are short chains of amino acids that can interact with skin cells. This particular ingredient is included in formulas to help neutralise free radicals and support the skin's natural defence mechanisms against environmental stressors.

Benefits for Your Skin

How It Works

The ingredient functions primarily through its antioxidant capacity—donating electrons to neutralise unstable free radical molecules that would otherwise damage skin cells and collagen. This helps reduce oxidative stress, a key driver of premature ageing and inflammation.

As a peptide, it may also interact with skin cells to upregulate protective proteins and enhance barrier function, though the precise mechanisms in living human skin remain incompletely understood.

Clinical Evidence & References

Published research specifically evaluating this ingredient in human skin is limited. The antioxidant and skin-protective claims are supported by broader peptide chemistry and general understanding of how similar peptide derivatives behave in cosmetic formulations.

Most evidence for efficacy comes from in vitro studies and ingredient supplier data. Real-world efficacy in finished products depends on formulation, concentration, and individual skin response. More independent clinical trials would help clarify its benefits in standard skincare use.

How to Use

This ingredient is typically found in serums, moisturisers, and protective creams. Use it as directed by the product instructions—usually once or twice daily. It pairs well with other antioxidants (such as vitamin C or niacinamide) and is generally compatible with most skincare routines. Allow time between application and sun exposure for full protective benefit if used in a daytime product.

Safety & Precautions

Generally well-tolerated in cosmetic concentrations. Sensitivity is rare, but those with peptide sensitivities or bacterial-derived ingredient concerns should patch-test first.

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