Peptides

Sr-Dog Polypeptide-1

INCI: SR-DOG POLYPEPTIDE-1

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Sr-dog Polypeptide-1

A peptide designed to support the skin's natural protective barrier

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Barrier repair, Dryness, Sensitivity

Usage Frequency

Daily

What Is Sr-Dog Polypeptide-1?

Sr-Dog Polypeptide-1 is a peptide—a short chain of amino acids—formulated to work with the skin's inherent defence mechanisms. Peptides are valued in skincare for their ability to communicate with skin cells and support structural integrity.

This ingredient is classified as a skin protectant, meaning it is intended to help maintain and reinforce the skin's barrier function, which is essential for preventing water loss and protecting against environmental stressors.

How It Works

Peptides operate by signalling to skin cells, essentially instructing them to strengthen and maintain barrier integrity. Sr-Dog Polypeptide-1 is believed to work by reinforcing the structural components that make up the skin's outermost layers.

A well-maintained barrier is better equipped to retain water, regulate inflammation, and defend against irritants and pollution.

Clinical Evidence & References

Published research specifically examining Sr-Dog Polypeptide-1 in skincare applications remains limited. While peptides as a class have demonstrated benefit in supporting skin health and barrier function, individual peptides vary in their efficacy.

More robust clinical data would be beneficial to establish the specific benefits and optimal concentrations of this ingredient in topical formulations.

How to Use

Sr-Dog Polypeptide-1 is typically found in serums, moisturisers, and barrier-repair products. It works well alongside other barrier-supporting ingredients such as ceramides and fatty acids. Apply to clean skin, morning and evening, or as directed by product instructions.

Safety & Precautions

Generally well-tolerated in topical skincare formulations. As with any ingredient, those with known sensitivities to peptides should perform a patch test before full application.

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