iS Clinical Pro-Heal Serum Advance+ Review

iS Clinical Pro-Heal Serum Advance+ is a fragrance-free vitamin C and retinol serum formulated for sensitive, reactive and post-procedure skin. If you're pregnant or breastfeeding, please contact our team for advice before use — this is the one serum in iS Clinical's range where the brand flags that caution explicitly. Read on for what's in it, how it's used, and who it suits.

What is Pro-Heal Serum Advance+?

Pro-Heal Serum Advance+ sits within iS Clinical's serum range as the vitamin C option aimed specifically at sensitive, compromised or reactive skin, rather than at resurfacing or general anti-ageing use. It's a lightweight, water-based, fragrance-free formula that iS Clinical positions for skin dealing with redness, blemishes, or recovery after an in-clinic treatment. For the rest of the range, see our iS Clinical reviews hub.

Key ingredients

According to iS Clinical's own product description, Pro-Heal Serum Advance+ is built around:

• L-Ascorbic Acid (Vitamin C) at 15%, delivered via the brand's time-release technology, which iS Clinical describes as giving continuous delivery over 72 hours — a manufacturer claim, not independently verified by us
• Retinol (Vitamin A) at 1%, working alongside the vitamin C
• Olive Leaf Extract, a botanical antioxidant
• Vitamin E (Tocopherol), a further antioxidant

The formula is explicitly fragrance-free, one of the main reasons iS Clinical positions it for reactive or easily-irritated skin rather than as a general-purpose vitamin C serum.

What it's formulated to help with

Per iS Clinical's own description, Pro-Heal Serum Advance+ is designed to:

• Provide antioxidant protection against environmental stressors
• Help calm the visible appearance of redness associated with sensitive or reactive skin, including rosacea and post-procedure skin
• Support the skin's appearance during recovery after in-clinic treatment
• Help improve the appearance of fine lines and skin tone and texture with consistent use

These are the brand's own stated aims, not claims we've independently tested — we haven't seen underlying clinical data to cite specific percentage results, so we've kept this section to what's stated on the product page.

How to use it

Pro-Heal Serum Advance+ is a lightweight, quick-absorbing serum designed to layer under moisturiser and SPF; iS Clinical positions it as a morning step given its vitamin C content. It's available in 15ml (£95) and 30ml (£157). As with any new active, particularly one containing retinol, introduce it gradually and watch how your skin responds before committing to daily use.

Pro-Heal Serum Advance+ vs Active Serum

iS Clinical also makes Active Serum, which works very differently: botanical AHA/BHA-adjacent ingredients for a resurfacing effect, typically used a few evenings a week, rather than Pro-Heal's vitamin C and retinol combination. Want gentle daily antioxidant support for sensitive skin? Pro-Heal is the closer fit. After evening resurfacing instead? Active Serum. See our full comparison for the detail.

Prefer a slightly different vitamin C strength or texture? Super Serum Advance+ is iS Clinical's other 15% vitamin C serum, built around a Copper Tripeptide and Centella asiatica complex rather than retinol.

Who it's for

Pro-Heal Serum Advance+ suits people with sensitive, reactive or compromised skin who want vitamin C's antioxidant benefits without fragrance, including those managing visible redness, blemish-prone skin, or skin recovering from a professional treatment. For a wider round-up of options in this space, see our best skincare for sensitive and post-procedure skin guide.

Think twice if you're already using a separate retinoid elsewhere in your routine — layering two retinol-containing products raises the risk of irritation, so introduce one at a time.

Pregnancy and breastfeeding

If you're pregnant or breastfeeding, please contact our team for advice before use.

Our verdict

Pro-Heal Serum Advance+ is a genuinely distinct option within iS Clinical's serum line-up: a fragrance-free vitamin C and retinol combination built for skin that reacts badly to most antioxidant serums. It won't suit everyone — anyone pregnant or breastfeeding needs to check with a clinician first, and retinol users already on a separate retinoid should avoid doubling up — but for sensitive, reactive or recently-treated skin wanting antioxidant support without fragrance, it fills a specific gap the rest of the range doesn't.

FAQs

Is iS Clinical Pro-Heal Serum Advance+ safe in pregnancy?

If you're pregnant or breastfeeding, please contact our team for advice before use.

Does it contain retinol?

Yes — iS Clinical's own product description lists 1% Retinol (Vitamin A) alongside 15% L-Ascorbic Acid (Vitamin C) as the formula's key actives.

iS Clinical Active Serum vs Pro-Heal Serum Advance+?

They're built for different jobs. Active Serum uses botanical resurfacing ingredients for a handful of evenings a week, while Pro-Heal Serum Advance+ is a fragrance-free vitamin C and retinol serum for daily antioxidant support on sensitive skin. See our full comparison for the detail.

Is it fragrance-free?

Yes, iS Clinical states the formula is fragrance-free, which is part of why it's positioned for sensitive and reactive skin types.

How long does a bottle last at once-daily use?

As a lightweight, water-based serum applied once a day, the 15ml size tends to suit shorter-term or trial use, while the 30ml size is better value for ongoing daily use — exact longevity depends on how much product you apply each time, so we can't give a precise figure.