iS Clinical Super Serum Advance+ Review
The Verdict
Super Serum Advance+ is a solid, concentrated choice if you want a single fridge-stored Vitamin C treatment step rather than a multi-product routine, and its copper-peptide technology sets it apart from the brand's other Vitamin C options. It's not the right pick if you'd rather avoid fridge storage or want retinol in the same formula — see the Pro-Heal Serum Advance+ review for that alternative.
iS Clinical Super Serum Advance+ | Vitamin C Serum | 15ml & 30ml
£95.00
iS Clinical Super Serum Advance+ is a 15% L-Ascorbic Acid (Vitamin C) treatment serum built around bioidentical Copper Tripeptide-1 Growth Factor. It's the brand's flagship vitamin C formula, aimed at dullness, uneven tone and early fine lines, and is fridge-recommended. It layers under moisturiser and SPF as a daily antioxidant step, and suits normal, combination and ageing skin wanting one concentrated treatment product.
What's in it
The formula is built around a time-released 15% L-Ascorbic Acid alongside Copper Tripeptide-1 Growth Factor, a bioidentical peptide complex. It's supported by a botanical antioxidant blend — Centella Asiatica, Arbutin and Polyporus Umbellatus (Mushroom) Extract — plus Hyaluronic Acid for hydration and Calcium Pantothenate (Vitamin B5). The texture is a lightweight, fast-absorbing liquid rather than a gel or cream, so it sits comfortably under other products without pilling.
How to use it
Apply a small amount to cleansed skin, then follow with moisturiser and, in the morning, a separate SPF — Vitamin C is a supporting antioxidant step, not a replacement for sun protection. Some users notice a brief tingling sensation on first use, particularly if new to Vitamin C serums; this typically settles within the first few applications as skin adjusts. Because the formula is fridge-recommended, storing it in the fridge helps preserve the active ingredients between uses; check the product packaging for the brand's specific storage guidance.
| Key actives | 15% L-Ascorbic Acid, Copper Tripeptide-1 Growth Factor, Hyaluronic Acid |
|---|---|
| Texture | Lightweight, fast-absorbing liquid serum |
| Sizes | 15ml and 30ml |
| Storage | Fridge-recommended |
| Suitable for | All skin types, including sensitive and acne-prone, per the brand's own listing |
Who it suits
This is a good fit if you want one concentrated Vitamin C step rather than several separate antioxidant and hydration products, and you're comfortable with a fridge-stored serum as part of your routine. If you'd prefer a Vitamin C serum that also contains retinol in the same formula, our Pro-Heal Serum Advance+ review covers that alternative. If the eye area specifically is your priority, the lower-strength, eye-safe C Eye Serum Advanced+ review is built for that job rather than the whole face.
Super Serum Advance+ vs iS Clinical's other Vitamin C serums
iS Clinical sells several Vitamin C options at different strengths and with different supporting technologies, and it's easy to pick the wrong one on percentage alone. Our Super Serum Advance+ vs GeneXC Serum comparison sets this formula's copper-peptide technology against GeneXC's higher-percentage, enzyme-based approach, covering storage, texture and which is the better starting point. For a wider view of where this sits against the range as a whole, our guide to the best iS Clinical serums for anti-ageing is worth reading before you buy. If you're comparing Vitamin C serums beyond the iS Clinical range, our independent guide to the best vitamin C serums in the UK covers the wider market.
Understanding L-Ascorbic Acid
L-Ascorbic Acid is the pure, most-studied form of Vitamin C used in skincare, and the one this serum is built around. For a fuller explanation of how it works and how it compares with other Vitamin C derivatives, see our Vitamin C glossary entry.
Pregnancy and breastfeeding
If you're pregnant or breastfeeding, please contact our team for advice before use.
Our approach
The ingredients, texture and usage details above are drawn from this product's live Shopify listing. We haven't repeated the brand's own scar- or stretch-mark-specific clinical claims here, since we can't independently verify the underlying study data — see the data gap below. We don't run star ratings on this page; it's an independent breakdown to help you decide if this is the right serum for you, not a review-platform score.