← Back to iS Clinical Reviews

iS Clinical Youth Intensive Creme Review

4 min read Updated Aug 20, 2026
iS Clinical Youth Intensive Creme in a lifestyle bathroom setting — Skintique review

The Verdict

An intensive, jar-format anti-ageing moisturiser for mature or dry skin that wants a retinoid and a vitamin C ester in one step. The rich texture and citrus scent won't suit everyone, and the acid content means it's one to build up to rather than use nightly from the start.

iS Clinical Youth Intensive Creme | Anti-Ageing Treatment | 50g

iS Clinical Youth Intensive Creme | Anti-Ageing Treatment | 50g

£234.00

Shop this product →

What is iS Clinical Youth Intensive Creme?

iS Clinical Youth Intensive Creme is a rich, 50g jar moisturiser built around Retinyl Palmitate and Tetrahexyldecyl Ascorbate, a stabilised vitamin C ester. It's formulated to help improve the appearance of fine lines, dehydration and uneven tone in mature or dry skin. The texture is dense and cushioning, with a natural citrus scent from Brazilian blood orange extract, and it's best introduced gradually rather than applied nightly from day one.

Key ingredients

The formula combines a retinoid, an antioxidant vitamin C ester, and supporting hydrators and peptides. Full INCI has not been independently verified for this page — see the data gap note below.

IngredientWhat it's included for
Retinyl PalmitateA gentler, ester form of vitamin A, included to help improve the appearance of fine lines and skin texture over time.
Tetrahexyldecyl AscorbateAn oil-soluble, stabilised vitamin C derivative, included as an antioxidant and to help improve the appearance of uneven tone.
Hyaluronic AcidA humectant included to support surface hydration and cushioning.
Copper Tripeptide complexA peptide ingredient included as part of the product's anti-ageing positioning; independent efficacy data has not been reviewed for this page.
Superoxide DismutaseAn antioxidant enzyme included to support the product's environmental-defence claims.

Texture, scent and how it feels

This is a genuinely rich, jar-format cream rather than a lightweight lotion — expect a cushioning, velvety finish that sits well under makeup once absorbed but leans heavier than a typical daytime moisturiser. It carries a noticeable natural citrus scent from Brazilian blood orange extract. If you're fragrance-avoidant or have reactive skin, this is worth knowing before you buy, as the scent is part of the formula rather than an optional add-on.

How to introduce it into your routine

Because the formula pairs a retinoid with mild fruit acids, it's worth introducing gradually rather than using nightly from the start. A sensible approach:

  • Patch test on a small area first, particularly if you have reactive or compromised skin.
  • Start with two to three evenings a week, building up as your skin adjusts.
  • Apply to clean, dry skin and follow with SPF the next morning, as with any retinoid-containing product.
  • Watch for tightness, flaking or sensitivity in the first few weeks, and step back frequency if this happens.

If you're pregnant or breastfeeding, please contact our team for advice before use.

Who it suits

iS Clinical positions this cream for mature, dry, dehydrated, normal and combination skin looking for an intensive anti-ageing moisturiser rather than a light daily lotion. Its acid content means it may be too active for very reactive or actively compromised skin without the gradual introduction above, and the citrus fragrance is a consideration for anyone avoiding scented skincare.

Layering it with the rest of your routine

As a rich, jar-format cream, Youth Intensive Creme works best as the last step of an evening routine, applied after any serums and before an occlusive balm if you use one. Because it already contains a retinoid and a vitamin C derivative, it's worth checking the rest of your routine for other strong actives — layering multiple retinoids, or combining it with a separate exfoliating acid on the same night, increases the chance of irritation. A simple pattern is: cleanse, treat with a serum if you use one, then apply Youth Intensive Creme as the final evening step, saving stronger exfoliants for a different night.

In the morning, follow with a broad-spectrum SPF, since retinoid-containing products can increase photosensitivity. The 50g jar size means a little goes a long way when used at the pea-to-almond-sized amount most jar creams call for, so factor that into how it compares on a cost-per-use basis against thinner, pump-dispensed moisturisers in the range.

Where it sits in the iS Clinical range

Youth Intensive Creme is one of several anti-ageing moisturisers in the iS Clinical line-up. For a lighter, more everyday hydrator, see Moisturizing Complex; for a more targeted anti-ageing formula, see Youth Complex; and for the neck and décolletage specifically, see Neckperfect Complex. For a wider view of how this cream compares within the brand's anti-ageing line-up, see our iS Clinical anti-ageing creams round-up, or browse the full iS Clinical brand review hub.

Key Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations