Peptides

Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2

INCI: METHIONYL SH-POLYPEPTIDE-7 SH-OLIGOPEPTIDE-1 SH-OLIGOPEPTIDE-2

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Methionyl Sh-polypeptide-7 Sh-oligopeptide-1 Sh-oligopeptide-2

A peptide complex that conditions and softens the skin barrier

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2?

Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 is a peptide complex derived from amino acids, the building blocks of proteins. It functions primarily as a skin conditioning agent and emollient in skincare formulations.

Peptides like this one are thought to interact with the skin's surface layers to improve texture and moisture retention. The oligopeptide components are shorter chains of amino acids that may enhance the overall conditioning effect.

How It Works

This peptide complex works primarily at the skin's surface, where it deposits and conditions the outer layers. The amino acid chains interact with the stratum corneum (the skin's outermost layer) to improve its texture and tactile feel.

By acting as an emollient, the peptide complex helps soften and smooth the skin. The oligopeptide components may also support the skin's natural moisturisation mechanisms, though the exact mechanism remains incompletely understood.

Clinical Evidence & References

Published clinical evidence specifically for this peptide complex is limited. Most data comes from manufacturer testing and ingredient safety assessments rather than independent peer-reviewed studies.

General peptide research suggests these ingredients can improve skin conditioning and hydration when used in formulations, though efficacy varies depending on concentration, formulation, and individual skin characteristics. More independent clinical research would help clarify its specific benefits.

How to Use

This ingredient works best as part of a complete skincare routine rather than as a standalone treatment. It is typically found in moisturisers, serums, and hydrating products where it supports the overall conditioning effect. Use it consistently as directed on your product packaging—usually once or twice daily depending on your skin's needs and the specific formulation.

Safety & Precautions

This peptide complex is generally considered well-tolerated in cosmetic formulations. As with any skincare ingredient, patch test if you have sensitive skin or are prone to reactions.

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