Myristoyl Hexapeptide-4

Myristoyl Hexapeptide-4 is a peptide—a short chain of amino acids—that has been chemically modified with a fatty acid (myristic acid) to enhance its ability to penetrate and remain in the skin. This modification allows the ingredient to function as a skin conditioning agent.In formulations, it works to support the skin's natural structure and moisture retention, making it a common inclusion in products targeting signs of ageing or compromised skin barrier function.

Myristoyl Hexapeptide-4 works primarily through its skin conditioning properties. The peptide chain signals to skin cells, whilst the fatty acid component allows it to integrate into the skin's lipid matrix—the fatty substances that hold skin cells together and prevent moisture loss.This dual action may help stabilise the skin barrier and improve hydration levels over time, though the exact molecular mechanisms in human skin remain incompletely characterised.

This ingredient is typically found in moisturisers, serums, and anti-ageing formulations at concentrations that allow it to work alongside other actives. It is stable in most formulation types and does not require special storage conditions beyond standard cool, dry storage. Use as directed on the product label, usually once or twice daily as part of your routine.

Myristoyl Hexapeptide-4 is generally well-tolerated across skin types. As with any new ingredient, patch test if you have known sensitivities to peptides or fatty acid derivatives.