Peptides

Myristoyl Nonapeptide-2

INCI: MYRISTOYL NONAPEPTIDE-2

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Myristoyl Nonapeptide-2

A peptide derivative used for skin conditioning in cosmetic formulations

Best For Skin Types

All

Addresses

Dryness, Texture

Usage Frequency

Daily

What Is Myristoyl Nonapeptide-2?

Myristoyl Nonapeptide-2 is a synthetic peptide—a chain of nine amino acids with a myristoyl (fatty acid) attachment. It functions as a skin conditioning agent in skincare products, working to support the skin's surface texture and appearance.

This ingredient belongs to a broader category of peptides used in cosmetics for their ability to interact with skin at a molecular level. The fatty acid component enhances how the ingredient penetrates and behaves within formulations.

How It Works

Peptides like Myristoyl Nonapeptide-2 work by interacting with skin cells and signalling pathways at the cellular level. The myristoyl (fatty acid) component makes the peptide more lipophilic, meaning it can penetrate the skin's outer layers more effectively than an unmodified peptide would.

Once in the skin, the ingredient is thought to support natural skin conditioning processes, though the exact mechanisms remain incompletely understood in cosmetic applications.

Clinical Evidence & References

Evidence specifically evaluating Myristoyl Nonapeptide-2 in cosmetic use is limited in the publicly available literature. While peptides as a category have shown promise in skincare research, individual peptides can behave quite differently depending on their structure and how they're formulated.

General research on peptides suggests they can support skin conditioning and cellular communication, but specific efficacy data for this particular ingredient would require targeted clinical studies.

How to Use

Myristoyl Nonapeptide-2 is typically formulated by manufacturers into serums, creams and moisturisers. Use as directed on the product label. Since it's a conditioning ingredient rather than an active treatment, results are likely subtle and cumulative with regular use.

Safety & Precautions

Peptides are generally well-tolerated in skincare. However, some individuals with fungal acne or Malassezia sensitivity may wish to patch test first, as certain peptide-derived ingredients can potentially feed fungal growth in susceptible individuals.

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