Natural Moisturizing Factor (NMF)

Reviewed by Kate · Last updated 18 Aug 2026

Also known as: Amino Acids, Peptides

Otherwise known as NMFs | Substances within skin’s uppermost layers that help keep it smooth

Addresses

Dehydration

EWG Safety Score

1 Low

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What Is Natural Moisturizing Factor (NMF)?

Natural Moisturizing Factors, otherwise known as NMFs, are substances within skin’s uppermost layers that help keep it smooth, hydrated and healthy-looking. Topical application helps reinforce skin’s surface so skin takes on a younger, replenished appearance.

NMFs make up an expansive group of ingredients that include amino acids, lactic acid, sodium PCA, various sugars and minerals, and peptides. Together with the naturally-occurring lipids in skin (examples would be ceramides, cholesterol, and glycosaminoglycans), NMF’s work to keep skin’s surface intact and supple.It is worth noting that routine exposure to sensitizing ingredients like drying cleanising agents and denatured alcohol cause serious depletion of skin’s natural moisturizing factors, leading to visibly dry, tight-feeling, flaky skin.

Clinical Evidence & References

Published Research

Acta-dermato Venerologica, November 2016, pages 880-884
Journal of Cosmetic Science, January-February 2010, pages 13-22
Skin Pharmacology and Physiology, September-October 2004, pages 207-213
Progressive Lipid Research, January 2003, pages 1-36
Journal of Lipid Research, May 2002, pages 794-804
Clinical Geriatric Medicine, February 2002, pages 103-120
Journal of the European Academy of Dermatology and Venereology, November 2002, pages 587-594
Journal of Investigative Dermatology, May 1996, pages 1096-1101
British Journal of Dermatology, November 1995, pages 679-685

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Other forms of Natural Moisturizing Factor (NMF)

These appear on ingredients lists under different names but are the same substance. Natural Moisturizing Factor (NMF) is the common form.

Natural Moisturizing Factor (NMF)

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