Pentaerythrityl Tetraisostearate
Reviewed by Daisy · Last updated 18 Aug 2026
Also known as: PTIS
Functions as a thickener, moisturising ingredient, and binding agent | Derived from the fatty acid isostearic acid
Addresses
EWG Safety Score
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What Is Pentaerythrityl Tetraisostearate?
Pentaerythrityl tetraisostearate is a non-aqueous ester that functions as a thickener, moisturizing ingredient, and binding agent in skin care products. It is derived from isostearic acid, a type of fatty acid.
Pentaerythrityl tetraisostearate is also known as PTIS. It is used in cosmetics in amounts from 0.1% to 55% (the highest concentration is in lipsticks, where it helps impart a glossy look as well as helps to disperse pigments).
The independent Cosmetic Ingredient Review panel found that pentaerythrityl tetraisostearate is safe as used in cosmetics, with no irritation or sensitization reported.
Clinical Evidence & References
Published Research
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International Journal of Toxicology, September 2015, pages 99S-112S [URL not found on page]
Frequently Asked Questions
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