Pentaerythrityl Tetraisostearate
Reviewed by Daisy · Last updated 18 Aug 2026
Also known as: PTIS
Functions as a thickener, moisturising ingredient, and binding agent | Derived from the fatty acid isostearic acid
At a glance
Addresses
EWG Safety Score
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What Is Pentaerythrityl Tetraisostearate?
Pentaerythrityl tetraisostearate is a non-aqueous ester that functions as a thickener, moisturizing ingredient, and binding agent in skin care products. It is derived from isostearic acid, a type of fatty acid.
Pentaerythrityl tetraisostearate is also known as PTIS. It is used in cosmetics in amounts from 0.1% to 55% (the highest concentration is in lipsticks, where it helps impart a glossy look as well as helps to disperse pigments).
The independent Cosmetic Ingredient Review panel found that pentaerythrityl tetraisostearate is safe as used in cosmetics, with no irritation or sensitization reported.
Clinical Evidence & References
Published Research
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International Journal of Toxicology, September 2015, pages 99S-112S [URL not found on page]
How widely it's used
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- PENTAERYTHRITYL TETRAISOSTEARATE
- EC Number
- 263-423-1
- Function
- Emollient, Emulsifying, Surfactant
Frequently Asked Questions
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Pelargonic Acid
A fatty acid that cleanses and conditions skin whilst helping formulations remain stable
Pentaerythrityl Distearate
A synthetic emulsifier that helps bind water and oil in skincare formulations
Phosphatidylglycerol
A phospholipid that supports skin cell renewal and barrier function
Phosphatidylserine
A cell membrane component that stabilises formulations and supports skin conditioning
Poloxamer 124
A synthetic polymer that stabilises and delivers active ingredients evenly across the skin
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