Peptides

Rh-Polypeptide-1

INCI: RH-POLYPEPTIDE-1

Reviewed by Kate · Last updated 14 Aug 2026

A peptide that supports skin's structural integrity and protective functions

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Loss of firmness, Barrier repair

Usage Frequency

Daily

What Is Rh-Polypeptide-1?

Rh-Polypeptide-1 is a peptide—a chain of amino acids—formulated to support skin conditioning and protection. Peptides are derived from proteins and are small enough to be incorporated into topical skincare products, where they can interact with the skin's surface and upper layers.

This ingredient functions as a skin conditioner and protectant, meaning it helps maintain skin texture and support the skin's natural defences against environmental stressors. It is typically used in small concentrations within broader skincare formulations.

How It Works

As skin ages, there is a progressive loss of structural proteins, particularly collagen in the dermis, alongside thinning of both the epidermis and dermis. This contributes to visible signs of aging such as loss of firmness and fine lines.

Rh-Polypeptide-1 works by conditioning the skin and supporting its protective barrier function. Whilst the precise mechanism is not extensively documented in published literature, peptides generally function by signalling to skin cells or by forming a conditioning film on the skin surface that helps retain moisture and support resilience.

Clinical Evidence & References

Peptides as a category are widely used in skincare and recognised for their conditioning properties. However, specific clinical evidence for Rh-Polypeptide-1 is limited in publicly available research. Most evidence for peptides in skincare comes from in vitro studies or manufacturer-sponsored research.

The ingredient is likely most effective as part of a comprehensive skincare routine addressing multiple aspects of skin ageing—including sun protection, hydration, and barrier support—rather than as a standalone solution.

How to Use

Rh-Polypeptide-1 is typically found in serums, moisturisers, and treatment products. It can be used daily as part of morning or evening skincare routines. Peptides are generally well-tolerated and can be layered with other actives, though as with any new ingredient, introduce it gradually to monitor your skin's response.

Safety & Precautions

Rh-Polypeptide-1 is generally considered well-tolerated and suitable for most skin types. No significant safety concerns are documented.

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