Rh-Polypeptide-22

Rh-Polypeptide-22 is a peptide—a short chain of amino acids—designed to function as a skin conditioning agent. Peptides are derived from or modelled on the building blocks of proteins found naturally in skin, making them compatible with the skin's own biochemistry.This ingredient works primarily to condition and soften the skin's surface, helping to improve texture and overall skin feel. It is typically used in formulations where skin conditioning and support of skin structure are desirable outcomes.

Peptides like Rh-Polypeptide-22 work by conditioning the skin's outer layers and interacting with the skin's natural proteins. Because they are small enough to penetrate the stratum corneum (the outermost layer), they can support the skin's structural proteins and help maintain hydration and elasticity.The mechanism is largely cosmetic conditioning rather than transformative—meaning it improves how skin looks and feels in the short term by hydrating and softening the surface, while potentially offering modest support to skin structure over repeated use.

Rh-Polypeptide-22 is typically found in serums, moisturisers, and treatment products. Apply to clean skin, morning and evening, as part of a regular routine. It works well in layered routines and pairs effectively with other conditioning ingredients. There is no need to use it in isolation; it complements other actives such as antioxidants or hydrating humectants.

Peptides are generally well-tolerated by most skin types. As with any new ingredient, patch test first if you have sensitive or reactive skin, though allergic reactions are uncommon.